When I have this installed on Microsoft Edge, there are a couple YouTube problems I have found.
First off, the advertisement for getting chrome cannot be clicked off, and I cannot change my YouTube channel profile by clicking the upper right button. (along with me not being able to X out of "You are now on YouTube as [x]).
Uninstalling helped all these problems.
YouTube problems.
Re: YouTube problems.
You could whitelist a certain site (and not uninstalling ABP) ==> click ABP icon, click the first voice in that menu (it should be like in chrome - I can't test it now)